Hypoplastic left heart syndrome (HLHS) is a congenital heart disease where the left ventricle is reduced in size.A forward genetic screen in mice identified SIN3A associated protein 130 Chairs w/CUSH/Table Set (3/CN) kDa (Sap130), part of the chromatin modifying SIN3A/HDAC complex, as a gene contributing to the etiology of HLHS.Here, we report the
While gazing at the Earth from orbit, some astronauts have described a cognitive shift known as the overview effect.Here we describe an analogous biological overview effect produced by looking at the tiny twig of humanity on the tree of life.We describe the increasingly precise phylogenetic tree of all life on Earth Cooking and how it shows us our
The purpose of this writing is to further examine the juridical implications of undue influence/abuse of circumstances against the aggrieved party accompanied by a form of legal protection for canceling an agreement with a concrete case from a court decision.In making agreements, the parties often abuse the principle of freedom of contract so as to
Mug Context Tangwang Mingmu granule (TWMM), a traditional Chinese medicine, has been widely used in the treatment of diabetic retinopathy (DR), the most common microvascular complication in diabetes mellitus.Objective To establish a method to select target compounds from herbs for a pharmacokinetic study using network pharmacology, which could be a
Immunotherapies are revolutionizing cancer care, producing durable Chairs w/CUSH/Table Set (3/CN) responses and potentially cures in a subset of patients.However, response rates are low for most tumors, grade 3/4 toxicities are not uncommon, and our current understanding of tumor immunobiology is incomplete.While hundreds of immunomodulatory protei